Diet plan and the Amazin brain best way to do this is to take the supplements ½ hour before meals. If you taking a 400mg supplement then take it ½ before breakfast in the morning and ½ before lunch time is best. If you taking an 800mg supplement then ½ before breakfast is best. There some confusion over how much to take so let's clear some of this up right now. It's recommended based on the clinical trials conducted to take a 400mg supplement 3/day or an 800mg supplement once or sometimes twice a day depending on Nerve renew results seen.